Ok, to muddy the waters, I do have glass visible filters in my line from tank to header. I also have a vent line to each tank. I fly it and can visually see what's happening and have run several dozen tanks of fuel through the system. The extra vent solved a problem with excess fuel being overboarded through the single vent into a single tank and giving me an asymetrical fuel load in flight.

You probably can over filterize (I just made that up) but to leave out essential filters is a no no. Bing carbs don't like dirt. (check the forum)
I have an inline filter at the tank, a gascolator, finger strainers for the big stuff in the tank, and whatever else comes organic to the carbs and fuel pump if anything.
I used the in line filters because of the old sloshing compound that was coming off my tanks. Now I have new tanks and thats not an issue but I like seeing if there is any crud in my fuel before it gets to far down stream.